Angelica sinensis, Dang Gui 当归
Dang Gui (TCM)
A. polymorpha var. chinensis (=A. sinensis)
Hooker, Icones Plantarum, 1891
Two different types of Dang Gui available on the Chinese Market. Left is the dried root with head and rootlets removed; below is the whole root with head and rootlets and which has been lightly steamed with alcohol before drying. (Adam, 2015, 2016)
Whole Angelica Dang Gui roots (Adam, 2024)
Members CLICK HERE for the PRO VERSION
Botanical name:
Angelica sinensis (syn. A. polymorpha var. sinensis)
Parts used:
Root
Temperature & Taste:
Warm, slightly moist. Sweet, Pungent
Classifications:
Uses:
1. Nourish the Blood, Regulates Menstruation:
-amenorrhea and dysmenorrhea; a main herb in TCM for Menstrual disorders
-blood deficiency syndrome, anemia, pernicious anemia
-skin diseases, eczema, dermatitis, neurodermatitis, psoriasis (with blood deficiency)
2. Moves the Blood, Eases Pain:
-important for Gynecological and Postpartum diseases with Blood stasis
-‘very important drug in treating postpartum diseases’; (Chen Cheng)
-pain due to blood stasis, trauma, bruising
3. Moisten the Intestines, Promote Stool:
-good to move the bowels in dryness, weakness or blood deficiency
-has an opening effect similar to the Opening Roots
4. Reduces Swelling, Promotes Healing:
-sores and abscesses that are slow-to-heal due to poor circulation
5. Clears Wind-Cold:
–‘good for all diseases caused by invasion of pathogenic Wind’. (Da Ming)
-can be used for Wind-type Headache
-this is not a modern indication but shows a relation to Western Angelica and Angelica Bai Zhi
Dose:
Decoction: 4–12 grams
Powder: 1–3 grams
Comment:
Preparation:
Main Combinations:
Tonic:
1. Weakness, Debility, Fatigue
i. Angelica Dang Gui … available in PRO version
ii. Qi and Blood deficiency, Angelica Dang Gui with … available in PRO version
Gynecology & Obstetrics:
2. Menstrual irregularity, Amenorrhea, Dysmenorrhea … available in PRO version
– Blood stasis or Blood deficiency but with signs of Heat, add … available in PRO version
– More pronounced Blood stasis, fixed pain, … available in PRO version
3. Dysmenorrhea, Angelica Dang Gui with … available in PRO version
4. Irregular Uterine Bleeding with signs of Blood Stasis, Angelica Dang Gui with … available in PRO version
5. Infertility from Blood and Essence deficiency, Angelica Dang Gui with … available in PRO version
6. Abdominal pain and Diarrhea during pregnancy, Angelica Dang Gui with … available in PRO version
7. Threatened Miscarriage, … available in PRO version
8. Postpartum deficiency, Angelica Dang Gui with … available in PRO version
Blood Stasis, Pain:
9. Trauma, Bruising, Fixed, stabbing pain, Fractures:
i. Angelica Dang Gui with … available in PRO version
ii. Angelica Dang Gui with … available in PRO version
iii. Angelica Dang Gui with … available in PRO version
10. Wind-Damp joint pain, Angelica Dang Gui with … available in PRO version
Other:
11. Insomnia, Irritability, Palpitations:
i. Angelica Dang Gui with … available in PRO version
ii. Angelica Dang Gui with … available in PRO version
12. Stroke with Hemiplegia, Numbness, loss of Speech, Angelica Dang Gui with … available in PRO version
13. Constipation from dryness and weakness:
i. combine Angelica Dang Gui with … available in PRO version
ii. with Blood stagnation, with … available in PRO version
14. Sores, Abscesses and Toxic Swellings, Angelica Dang Gui with … available in PRO version
Major Formulas:
Ba Zhen Tang
Bai He Gu Jin Tang
Bu Yang Huan Wu Tang
Bu Zhong Yi Qi Tang
Dang Gui Bu Xue Tang
Dang Gui Liu Huang Tang
Dang Gui Long Hui Wan
Dang Gui Shao Yao San
Dan Zhi Xiao Yan San (Jia Wei Xiao Yao San)
Die Da Wan
Du Huo Ji Sheng Tang
Fang Feng Tong Sheng San
Ge Xia Zhu Yu Tang
Gui Pi Tang
Huo Luo Xiao Ling Dan
Long Dan Xie Gan Tang
Sang Piao Xiao San
Shao Fu Zhu Yu Tang
Shi Quan Da Bu Tang
Si Wu Tang
Tian Wang Bu Xin Wan
Wu Hu San
Xiao Yao San
Xue Fu Zhu Yu Tang
Cautions:
1. Not used in those with Diarrhea
Main Preparations used:
Prepared root
GENERAL / REVIEW
–Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide.
–Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis.
–Quantitative analysis of marker compounds in Angelica gigas, Angelica sinensis, and Angelica acutiloba by HPLC/DAD.
COMBINATIONS
–The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC. on antioxidant activity and protective ability against cell injury.
–Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy.
–Combination of Astragalus membranaceous and Angelica sinensis Ameliorates Vascular Endothelial Cell Dysfunction by Inhibiting Oxidative Stress.
–The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function.
–A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury.
–Effect of Dangguibohyul-Tang, a Mixed Extract of Astragalus membranaceus and Angelica sinensis, on Allergic and Inflammatory Skin Reaction Compared with Single Extracts of Astragalus membranaceus or Angelica sinensis.
–The Extracts of Angelica sinensis and Cinnamomum cassia from Oriental Medicinal Foods Regulate Inflammatory and Autophagic Pathways against Neural Injury after Ischemic Stroke.
–Ultrafiltration Extract of Radix Angelica Sinensis and Radix Hedysari Attenuates Risk of Low-Dose X-Ray Radiation-Induced Myocardial Fibrosis In Vitro.
–Radix Angelica Sinensis and Radix Hedysari Ultrafiltration Extract Protects against X-Irradiation-Induced Cardiac Fibrosis in Rats.
–The effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration extract on X-irradiation-induced myocardial fibrosis in rats.
–Experimental Study on the Effect of Aconite and Angelica sinensis on Myocardial Ischemia Rats with Yang Deficiency and Blood Stasis.
–Effect of Panax ginseng combined with Angelica sinensis on the dissolution of ginsenosides and in chemotherapy mice hematopoietic function.
–Supercritical Fluid Extract of Angelica sinensis and Zingiber officinale Roscoe Ameliorates TNBS-Induced Colitis in Rats.
PROCESSING
–Screening study of blood-supplementing active components in water decoction of Angelica sinensis processed with yellow rice wine based on response surface methodology.
–Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products.
ANTI-INFLAMMATORY
–Anti-Inflammatory Effects of Angelica sinensis (Oliv.) Diels Water Extract on RAW 264.7 Induced with Lipopolysaccharide.
–Evaluation of the anti-inflammatory effects of volatile oils from processed products of Angelica sinensis radix by GC-MS-based metabolomics.
–Effects of volatile oils of Angelica sinensis on an acute inflammation rat model.
ANTIOXIDANT
–Optimization conditions for extracting polysaccharide from Angelica sinensis and its antioxidant activities.
IMMUNE EFFECTS
–Structural Characterization of an Alkali-Soluble Polysaccharide from Angelica sinensis and Its Antitumor Activity in Vivo.
–The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function.
–Structural analysis and immunoregulation activity comparison of five polysaccharides from Angelica sinensis.
–Immunomodulatory activity of polysaccharide isolated from Angelica sinensis.
–[Effects of Angelica sinensis polysaccharide on cell-mediated immunity].
HEPATOPROTECTIVE
–Angelica sinensis polysaccharide (ASP) attenuates diosbulbin-B (DB)-induced hepatotoxicity through activating the MEK/ERK pathway.
–Angelica sinensis polysaccharide attenuates CCl4-induced liver fibrosis via the IL-22/STAT3 pathway.
–Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro.
–[Protective effect of Angelica sinensis polysaccharide against liver injury induced by D-galactose in aging mice and its mechanisms].
–Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice.
–Metabolomics research on the hepatoprotective effect of Angelica sinensis polysaccharides through gas chromatography-mass spectrometry.
–Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism.
FATTY LIVER
–New understanding of Angelica sinensis polysaccharide improving fatty liver: The dual inhibition of lipid synthesis and CD36-mediated lipid uptake and the regulation of alcohol metabolism.
–Extraction and structural analysis of Angelica sinensis polysaccharide with low molecular weight and its lipid-lowering effect on nonalcoholic fatty liver disease.
–Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice.
PROTECTS FROM CELL INJURY
–The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC. on antioxidant activity and protective ability against cell injury.
ESTROGENIC
–Estrogenic activity of standardized extract of Angelica sinensis.
BLOOD STASIS
–Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products.
ANEMIA
–Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the Treg/Th17 ratio in aplastic anemia.
–Polysaccharide from Angelica Sinensis Suppresses Inflammation and Reverses Anemia in Complete Freund’s Adjuvant-induced Rats.
–[Spectrum-effect relationships on enriching blood activities of fresh and dry roots of Angelica sinensis].
–[Effects of Radix Hedysari, Radix Astragalus and compatibility of Angelica Sinensis on blood deficiency model mice induced by cyclophosphamide].
–Correction of Anemia in Chronic Kidney Disease With Angelica sinensis Polysaccharide via Restoring EPO Production and Improving Iron Availability.
–Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation.
–Integrated metabonomic-proteomic studies on blood enrichment effects of Angelica sinensis on a blood deficiency mice model.
–Haematopoietic effects of Angelica sinensis root cap polysaccharides against lisinopril-induced anaemia in albino rats.
–Protective effects of the roots of Angelica sinensis on strenuous exercise-induced sports anemia in rats.
–Urine metabonomic study for blood-replenishing mechanism of Angelica sinensis in a blood-deficient mouse model.
–Metabolomics study of hematopoietic function of Angelica sinensis on blood deficiency mice model.
–The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia.
CARDIOPROTECTIVE
–Angelica sinensis Polysaccharide Alleviates Myocardial Fibrosis and Oxidative Stress in the Heart of Hypertensive Rats.
–The protective effects of different compatibility proportions of the couplet medicines for Astragali Radix and Angelica sinensis Radix on myocardial infarction injury.
–Radix Angelica Sinensis and Radix Hedysari Ultrafiltration Extract Protects against X-Irradiation-Induced Cardiac Fibrosis in Rats.
–Angelica sinensis: a novel adjunct to prevent doxorubicin-induced chronic cardiotoxicity.
MYOCARDIAL ISCHEMIA
–Experimental Study on the Effect of Aconite and Angelica sinensis on Myocardial Ischemia Rats with Yang Deficiency and Blood Stasis.
MYOCARDIAL INFARCTION
–Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction.
PULMONARY FIBROSIS
–Angelica Sinensis Polysaccharide Suppresses Epithelial-Mesenchymal Transition and Pulmonary Fibrosis via a DANCR/AUF-1/FOXO3 Regulatory Axis.
–Angelica sinensis is effective in treating diffuse interstitial pulmonary fibrosis in rats.
–[Protection of Angelica sinensis against radiation-induced pulmonary fibrosis in mice].
NEUROPROTECTIVE
–Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress.
ANTI-DEPRESSANT
–The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress-Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats.
ISCHEMIC STROKE
–Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke.
–The Extracts of Angelica sinensis and Cinnamomum cassia from Oriental Medicinal Foods Regulate Inflammatory and Autophagic Pathways against Neural Injury after Ischemic Stroke.
CEREBRAL ISCHEMIA
–Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK-mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats.
–Angelica sinensis extract protects against ischemia-reperfusion injury in the hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats.
–Angelica sinensis Exerts Angiogenic and Anti-apoptotic Effects Against Cerebral Ischemia-Reperfusion Injury by Activating p38MAPK/HIF-1[Formula: see text]/VEGF-A Signaling in Rats.
TRAUMATIC BRAIN INJURY
–A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury.
ANTI-AGEING
–Angelica Sinensis Polysaccharide Suppresses the Aging of Hematopoietic Stem Cells Through Sirt1/FoxO1 Signaling.
–Angelica Sinensis Polysaccharide Prevents Hematopoietic Stem Cells Senescence in D-Galactose-Induced Aging Mouse Model.
MEMORY LOSS
–Angelica sinensis reduced Aβ-induced memory impairment in rats.
ALZHEIMER’S DISEASE
–Optimal Formula of Angelica sinensis Ameliorates Memory Deficits in β-amyloid Protein-induced Alzheimer’s Disease Rat Model.
OBESITY
–Angelica sinensis Suppresses Body Weight Gain and Alters Expression of the FTO Gene in High-Fat-Diet Induced Obese Mice.
–Anti-obesity effect of radix Angelica sinensis and candidate causative genes in transcriptome analyses of adipose tissues in high-fat diet-induced mice.
COLITIS
–Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice by Angelica Sinensis Polysaccharide.
–Supercritical Fluid Extract of Angelica sinensis and Zingiber officinale Roscoe Ameliorates TNBS-Induced Colitis in Rats.
ULCERATIVE COLITIS
–Protective effect of polysaccharides from Angelica sinensis on ulcerative colitis in rats.
OSTEOPOROSIS
–Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
–Anti-osteoporotic effects of Angelica sinensis (Oliv.) Diels extract on ovariectomized rats and its oral toxicity in rats.
OSTEOARTHRITIS
–Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway.
–Oxidative stress in osteoarthritis and antioxidant effect of polysaccharide from angelica sinensis.
–Angelica sinensis and osteoarthritis: a natural therapeutic link?
RHEUMATOID ARTHRITIS
–Angelica sinensis polysaccharide improves rheumatoid arthritis by modifying the expression of intestinal Cldn5, Slit3 and Rgs18 through gut microbiota.
CERVICAL SPONDYLOSIS
–Clinical effect of cervical paravertebral nerve block combined with Mailuoning and Angelica sinensis in treatment of nerve-root type cervical spondylosis.
NEPHROPROTECTIVE
–A branched arabinoglucan from Angelica sinensis ameliorates diabetic renal damage in rats.
–[Protective effect of Angelica sinensis polysaccharides on subacute renal damages induced by D-galactose in mice and its mechanism].
–Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro.
–Potential nephroprotective effects of the Chinese herb Angelica sinensis against cisplatin tubulotoxicity.
KIDNEY STONES
–Protective potential of Angelica sinensis polysaccharide extract against ethylene glycol-induced calcium oxalate urolithiasis.
DIABETIC NEPHROPATHY
–Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy.
CANCER
–The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron Metabolism by Regulating Hepcidin in Tumor-Bearing Mice.
–Effect of Angelica sinensis Root Extract on Cancer Prevention in Different Stages of an AOM/DSS Mouse Model.
–Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels.
–The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice.
BLADDER
–Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer.
BRAIN
–Angelica sinensis polysaccharide inhibits proliferation, migration, and invasion by downregulating microRNA-675 in human neuroblastoma cell line SH-SY5Y.
–The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo.
–The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo.
COLORECTAL
–[Colorectal cancer preventive effect of combined administration of phenolic acids and supercritical extracts from Angelica sinensis].
–[Chemo-preventive effect of Angelica sinensis’ supercritical extracts on AOM/DSS-induced mouse colorectal carcinoma associated with inflammation].
–Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.
GASTRIC
–Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition.
LEUKAMIA
–Leukemia cells apoptosis by a newly discovered heterogeneous polysaccharide from Angelica sinensis (Oliv.) Diels.
–Structure characterization and anti-leukemia activity of a novel polysaccharide from Angelica sinensis (Oliv.) Diels.
–[Biological mechanisms of human-derived leukemia stem cells senescence regulated by Angelica sinensis polysaccharide].
–Angelica sinensis polysaccharide induces erythroid differentiation of human chronic myelogenous leukemia k562 cells.
–[Experimental study on aging effect of Angelica sinensis polysaccharides combined with cytarabine on human leukemia KG1alpha cell lines].
LIVER
–Structural Characterization of an Alkali-Soluble Polysaccharide from Angelica sinensis and Its Antitumor Activity in Vivo.
LUNG
–The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function.
MELANOMA
–Structures and anti-melanoma activities of two polysaccharides from Angelica sinensis (Oliv.) Diels.
USE IN BREAST CANCER
–Tumorigenic risk of Angelica sinensis on ER-positive breast cancer growth through ER-induced stemness in vitro and in vivo.
–A population-based case-control study on the association of Angelica sinensis exposure with risk of breast cancer.
–Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels.
–Angelica sinensis polysaccharides promotes apoptosis in human breast cancer cells via CREB-regulated caspase-3 activation.
–Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate?
CHEMOTHERAPY SIDE EFFECTS
–Angelica sinensis Polysaccharides Ameliorate Stress-Induced Premature Senescence of Hematopoietic Cell via Protecting Bone Marrow Stromal Cells from Oxidative Injuries Caused by 5-Fluorouracil.
–Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro.
–Potential nephroprotective effects of the Chinese herb Angelica sinensis against cisplatin tubulotoxicity.
–Angelica sinensis: a novel adjunct to prevent doxorubicin-induced chronic cardiotoxicity.
RADIOPROTECTIVE
–Ultrafiltration Extract of Radix Angelica Sinensis and Radix Hedysari Attenuates Risk of Low-Dose X-Ray Radiation-Induced Myocardial Fibrosis In Vitro.
–The effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration extract on X-irradiation-induced myocardial fibrosis in rats.
DERMATITIS
–Topical Application of Angelica sinensis Improves Pruritus and Skin Inflammation in Mice with Atopic Dermatitis-Like Symptoms.
PROMOTES HAIR GROWTH
–Angelica sinensis induces hair regrowth via the inhibition of apoptosis signaling.
