Eleutherococcus, Siberian Ginseng, Ci Wu Jia 刺五加
Russian Ginseng, Spiny Acanthopanax, Devil’s Shrub, Eleutherococcus Ginseng
Ci Wu Jia (TCM)
Botanical name:
Eleutherococcus senticosus (syn. Acanthopanax senticosus, Hedera senticosa)
Parts used:
Root, Root-bark or Stem-bark
Temperature & Taste:
Warm, dry. Pungent, slightly Bitter
Classification:
Uses:
1. Tonifies Spleen, Increases Qi:
-fatigue, lethargy
-poor appetite, digestive weakness
-Spleen deficiency from overthinking or worry
-Altitude Sickness
-enhances Immunity
2. Warms and Strengthens the Kidneys:
-weakness of the Lower back and Knees
-Osteoporosis-Failure to Thrive in children, growth retardation
-Impotence, has been used as an aphrodisiac
-Diabetes (proven hypoglycemic effect)
3. Benefits the Heart and Brain, Calms the Spirit:
-Insomnia, dream-disturbed sleep, nervousness, restlessness
-Poor concentration, Confusion, mild depression, Fear
-enhances Memory
-Heart deficiency
4. Moves the Blood, Clears the Channels:
-Cold extremities from poor circulation
-Blood stasis with fixed pain
-Vasodilator and circulatory stimulant effect
Main Combinations:
1. Dementia, Alzheimer’s Disease: Siberian Ginseng, … available in PRO version
2. Chronic Fatigue:
i. Siberian Ginseng with … available in PRO version
ii. Siberian Ginseng with … available in PRO version
3. Failure to thrive in children, enhance growth, Siberian Ginseng, … available in PRO version
4. Altitude Sickness:
i. Siberian Ginseng with … available in PRO version
ii. Siberian Ginseng with … available in PRO version
5. Hydrocephalus: Siberian Ginseng with … available in PRO version
6. Cold extremities, Siberian Ginseng with … available in PRO version
7. Osteoarthritis, Siberian Ginseng, … available in PRO version
8. Lung Cancer: Siberian Ginseng, … available in PRO version
9. Colorectal Cancer, Siberian Ginseng, … available in PRO version
10. Prostate Cancer, Siberian Ginseng, … available in PRO version
11. Kidney / Adrenal deficiency:
i. Siberian Ginseng with … available in PRO version
ii. Siberian Ginseng with … available in PRO version
12. Prostatitis, Siberian Ginseng with … available in PRO version
11. Impotence, Aphrodisiac:
i. Siberian Ginseng with … available in PRO version
ii. Siberian Ginseng with … available in PRO version
Major Formulas:
Cautions:
1. Caution in Heat diseases and Yin deficiency.
2. Commission E listed high blood pressure as a contraindication.
Drug Interactions::
1. Suggested to avoid using with stimulants including caffeine, and antipsychotic medication.
2. May increase serum digoxin levels.
Main Preparations used:
GENERAL / REVIEW
–The Chemical Characterization of Eleutherococcus senticosus and Ci-wu-jia Tea Using UHPLC-UV-QTOF/MS
ANTI-INFLAMMATORY:
–A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
ANTIOXIDANT:
–The Antioxidant Activity and Their Major Antioxidant Compounds from Acanthopanax senticosus and A. koreanum
ADAPTOGEN:
–Adaptogens Stimulate Neuropeptide Y and Hsp72 Expression and Release in Neuroglia Cells
–Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity
IMMUNOMODULATORY:
–A review on the immunomodulatory activity of Acanthopanax senticosus and its active components
–Effects of Acanthopanax senticosus Polysaccharide Supplementation on Growth Performance, Immunity, Blood Parameters and Expression of Pro-inflammatory Cytokines Genes in Challenged Weaned Piglets
FATIGUE:
–Effects of Eleutherococcus senticosus Cortex on Recovery from the Forced Swimming Test and Fatty Acid β-Oxidation in the Liver and Skeletal Muscle of mice
–Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus
ENHANCES MEMORY / COGNITION:
–Memory Enhancement by Oral Administration of Extract of Eleutherococcus senticosus Leaves and Active Compounds Transferred in the Brain
–Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults
ALZHEIMER’S DISEASE:
–Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease
–Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer’s models
–Potential Natural Products for Alzheimer’s Disease: Targeted Search Using the Internal Ribosome Entry Site of Tau and Amyloid-β Precursor Protein
ENHANCES BONE GROWTH:
–Effect of HT042, Herbal Formula, on Longitudinal Bone Growth in Spontaneous Dwarf Rats
–Astragalus Extract Mixture HT042 Improves Bone Growth, Mass, and Microarchitecture in Prepubertal Female Rats: A Microcomputed Tomographic Study
–Effects of Eleutherococcus Extract Mixture on Endochondral Bone Formation in Rats
OSTEOARTHRITIS:
–Effects of AIF on Knee Osteoarthritis Patients: Double-blind, Randomized Placebo-controlled Study
–Traditional Chinese medicine in patients with osteoarthritis of the knee
OSTEOPOROSIS:
–Preventive Effects of Eleutherococcus senticosus Bark Extract in OVX-Induced Osteoporosis in Rats
DIABETES:
–Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice
ANTI-AGEING:
–Current Perspective in the Discovery of Anti-aging Agents from Natural Products
CANCER:
–Anti-tumour effects of polysaccharide extracted from Acanthopanax senticosus and cell-mediated immunity
LUNG CANCER:
–Can Aidi injection alleviate the toxicity and improve the clinical efficacy of radiotherapy in lung cancer?: A meta-analysis of 16 randomized controlled trials following the PRISMA guidelines
–Aidi Injection, a Traditional Chinese Medicine Injection, Could Be Used as an Adjuvant Drug to Improve Quality of Life of Cancer Patients Receiving Chemotherapy: A Propensity Score Matching Analysis
–Can Aidi injection restore cellular immunity and improve clinical efficacy in non-small-cell lung cancer patients treated with platinum-based chemotherapy? A meta-analysis of 17 randomized controlled trials following the PRISMA guidelines
–Clinical Efficacy and Safety of Aidi Injection Plus Docetaxel-Based Chemotherapy in Advanced Nonsmall Cell Lung Cancer: A Meta-Analysis of 36 Randomized Controlled Trials
–Has aidi injection the attenuation and synergistic efficacy to gemcitabine and cisplatin in non-small cell lung cancer? A meta-analysis of 36 randomized controlled trials
–Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer
–Astragalus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: a meta-analysis of 65 clinical trials enrolling 4751 patients
COLORECTAL CANCER:
–Chinese Herbal Medicine and Fluorouracil-Based Chemotherapy for Colorectal Cancer: A Quality-Adjusted Meta-Analysis of Randomized Controlled Trials
PROSTATE CANCER:
–Prevention of Prostate Tumor Development by Stimulation of Antitumor Immunity Using a Standardized Herbal Extract (Deep Immune®) in TRAMP Mice
