Organotherapy

Outlines of Organotherapy

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Chicken Gizzard skin, still widely used in TCM,
it has also been traditionally used in the West.

The following is extracted primarily from ‘Outlines of Organotherapy’, Henry R. Harrower, M.D., 1918.
Introduction
Organotherapy is the use of powders or extracts prepared from animal glands and organs. It was in vogue during the early 20th century, but its origins can be traced back through centuries of Traditional Medicine.
The use of Testicles, Genitals, bird Brains, Chicken Gizzard, Ovaries, Uterus, Placenta and other organs and body parts can be found throughout Traditional Medicine texts of both East and West. Likewise various Glands and Organs are or were used as foodstuff, Lung, Liver, Brain, Thymus, Pancreas, Testicles and Blood are or were all commonly eaten.
Organotherapists expanded this traditional practice by making more refined extracts, some of which were injectable, as well as greatly expanding the organs and glands which they used. Also, Organotherapists particularly relied on endocrine gland preparations, and this is where they differ from the use of organs in Traditional Medicine. The latter rarely used endocrine glands, with the exception of Testes. With the understanding of hormones, the use of whole gland extracts preceded the modern use of synthetic isolated hormones widely used in modern medicine.
As with whole plant preparations versus isolated plant extracts, there is an advantage in the use of whole glands. Nutrition including amino acids and trace elements appropriate to the gland are consumed when the whole gland is taken, meaning that their is biological support for the gland being treated rather than just a hormonal stimulation or replacement for hypofunctioning glands. For this reason, it was noted by Organotherapists that isolated hormones (such as adrenalin) were more effective in acute cases, while the whole gland (adrenals) were more effective in chronic conditions.
Commonly used Organs and Glands

Most used Glandular Extracts: Most used Organ Extracts:
  Adrenal   Brain
  Thymus   Stomach
  Pancreas   Spleen
  Pituitary   Kidney
  Thyroid   Liver
  Parathyroid Other:
  Testes   Bile
  Prostate   Blood
  Ovary   Bone Marrow
  Placenta

Glands

Adrenal Prostate
Suprarenal capsule from cattle or other domestic animal. Prostate gland of cattle
Prepared as a powder. -prostatic hypertrophy with retention, strangury; Prostatitis
i. Adrenal Medulla -diuretic
-Asthma, Bronchial spasm DOSE: 3–5 grains, occasionally up to 10 grains
-Addison’s disease; Grave’s Disease Ovary and Corpus Luteum
-Collapse and Shock Ovarian extract from domestic animals; Corpus Luteum of pregnant cows or sows was used the same.
-Heart failure Ovaries or Uterus of animals has occasionally been used in Traditional Medicine, usually to aid fertility.
-Vomiting of Pregnancy -regulates menstruation
-acute cases were noted to be better treated with adrenaline; chronic cases are better treated with whole gland extract. -organic or functional ovarian deficiency
DOSE: 1-10th–¼ grain every hour in acute cases; 1–2 grains three times daily in chronic cases. -anemia, obesity, skin diseases associated with the ovaries
ii. Adrenal Total Gland -amenorrhea, dysmenorrhea
-asthenia, fatigue; all conditions of a ‘run-down’ nature. -PMS, Menopause; Hot flushes
-cardiac insufficiency, hypotension -neurasthenia and epilepsy associate with menstruation
-tuberculosis, cachexia CAUTION: Not used in pregnancy; Ovarian Hyperactivity (mental and nervous excitability)
CAUTION: Diabetes mellitus; Hypertension COMBINATION: often with Thyroid extract; also Pituitary gland (total) extract.
DOSE: ½–2½ grains three or four times daily before meals. DOSE: 2–5 grains, increasing to 15–20 grains, morning and night. It is stopped during menstruation.
iii. Adrenal Cortex Thyroid
-anti-toxic Dried Thyroid gland of sheep and lambs (preferably from sheep grazing near the sea).
-gonad insufficiency; aspermia; impotence -Hypothyroidism
-enhances healing of fractures -simple Goiter
DOSE: 2–5 or more grains, three times daily -senility, mental disorders, insanity, hysteria, melancholy, dementia, other psychoses
Thymus (whole gland) -obesity, anemia
Dried thymus from calves (preferably fetal animals) -dermatoses, especially pruritus, ichthyosis, pityriasis rubra, scleroderma, psoriasis and even lupus
Thymus gland was regularly eaten as ‘Sweetbread’ in our grandparents generation. -dysmenorrhea, amenorrhea, mastodynia, chlorosis, menopause
-controls mineral metabolism, especially calcium -rheumatism, arthritis
-stimulates hemopoietic and lymphatic glands -said to ‘keep the arteries soft’ in elderly patients
-regulates growth and activity of sex organs in childhood -’Thyroid extract has been used in an almost innumerable number of conditions’.
-malnutrition, delayed development in children DOSE: dose is very variable, and changes with the patient. 1-10th–¼ grain for mild hyperthyroidism; inactive or absent Thyroid gland, 1 grain three times daily. In some instances, doses of 10 grains daily were required.
-exophthalmic goiter, Grave’s disease CAUTION: not in hyperthyroidism, Graves disease, palpitations and rapid heart rate.
-rheumatoid arthritis Overdose symptoms include irritability, tachycardia, insomnia
DOSE: 5 or more grains, start with low doses, increasing gradually COMBINATION: combines well with Iodine.
Pancreas ‘Thyroid is “the great organotherapeutic synergist,” small doses frequently adding much to the therapeutic values of many other glandular extracts’.
Dried Powder from cattle or pigs. Parathyroid
Like Thymus, Pancreas was sometimes formerly eaten as ‘Sweetbread’. Glands usually derived from cattle
-contains enzymes to benefit digestion; digestive weakness, Indigestion -parathyroid insufficiency
-Tuberculosis and Cancer (to ‘lower the anti-tryptic index’) -restlessness, insomnia
DOSE: 3–10 grains, best taken one hour after meals -principally for Parkinson’s disease (obvious benefit in 80% of cases)
Pituitary DOSE: 1-10th–1-20th grain two or three times daily, must be taken for months
While Pituitary is not used in Traditional Medicine, the tonic application of bird Brains, especially Sparrow Brains, suggest that Pituitary hormones may be playing a role. COMBINATIONS: Liver; Bile salts
i. Posterior lobe: Testicles
Dried posterior pituitary of cattle From Rams or Bulls (or Deer)
-induces and hastens Labor Testicles from Bull, Rams and Deer have been long used in Traditional Medicine.
-postpartum bleeding -testicular insufficiency: sterility, debility, premature senility, impotence
-marked diuretic in uremia, anuria and edema -sexual neurosis, neurasthenia
-fecal impaction and acute intestinal stoppage -infantilism
-Hyperthyroidism -amenorrhea
-Bronchial Asthma -menopause, hot flushes
-‘one of the most remarkable of the organotherapeutic extracts and its physiologic action is evident in a widely varying range of clinical cases’. DOSE: 3–10 grains, beginning with small doses, increase as needed
CAUTIONS: Not used in Pregnancy or early stages of Labor COMBINATION: Adrenal (total); Prostate; small doses of Thyroid
COMBINATIONS: with adrenal in Addison’s Disease, Asthma and other uses
DOSE: ½–3 grains in powders or tablets, 3 or 4 times daily (up to 15–30 grains was used on occasion).
ii. Anterior Pituitary
Anterior pituitary of cattle
-functional pituitary disorders including infantilism, delayed mental development
-certain types of amenorrhea
-asexual individuals
-Diabetes insipidus
-Bronchial Asthma
DOSE: 1–5 grains, 3–6 times daily; in Asthma, 2½ grains 4 times daily
COMBINATION: with Thyroid or Gonads
iii. Total Gland
Complete pituitary from cattle
-muscular tonic
-diuretic; anuria
-general tonic
-cardiac asthenia, tachycardia
DOSE: ½–1 grain after meals and at bedtime
COMBINATION: general tonic, with Adrenal; run-down, with small doses of Thyroid

Organs

Brain Kidney
Defatted powder of Brain (sometimes with spinal cord) of sheep Powder of glomerular substance of the kidneys of cow, sheep or pigs
-Mental and nervous disorders, including depression, melancholia, hysteria, epilepsy, neurasthenia -specific neutralising effect in toxemia
Brains have been used in Traditional Medicine, most commonly, the brains of birds, especially Sparrows brains, used in Aphrodisiac compounds. Chicken brains were used to strengthen the Wit and Memory. -diuretic; anuria, albuminuria, ascites, edema
DOSE: 1–3 grains, 3–4 times daily DOSE: 5–15 grains of the powder after meals
Lungs Liver
Dried Lungs from young animals, preferably Lamb Dried Liver of Cattle or pigs;
Fox lungs was traditionally used in the Western Tradition for Asthma and Lung disease. Various Liver has been used in Traditional Medicine.
-Lung tonic -Liver insufficiency
-chronic bronchitis, purulent pleurisy, lung abscess, etc.; –mediocre results in phthisis, bronchial asthma and emphysema -atrophic cirrhosis, alcoholic liver
DOSE: 10–20 grains -adjunct in cholelithiasis
Spleen -detoxicant in various diseases including gout, rheumatism
Spleen from calves, pigs or sheep -anti-hemorrhagic
-malnutrition; increases weight and nutrition in wasting and phthisis -Diabetes associated with Liver dysfunction
-anemia; blood tonic DOSE: 15–60 grains (1–4 grams), best given just before meals
-bone and glandular tuberculosis CAUTION: not used in Pancreatic Diabetes
DOSE: 5–15 grains COMBINATIONS: Bile; Spleen; sometimes Thyroid
COMBINATIONS: Thyroid; Liver Heart
Heart of a Calf or other domestic animals was occasionally used.
Used to strengthen a weak Heart
DOSE: 15–60 grams, usually in decoction or as a distilled water (Traditionally)

Other

Bile Bone Marrow
Bile of cattle or pig, dried or inspissated Medullary portion of the long bones of young cattle
Bile has been much used in Traditional Medicine, Bear Bile being the most notorious. Bile is used in Traditional Medicine to clear Heat and Toxin, clear Liver Heat, clear Heat and Wind to stop Spasms. Bile is also much used to benefit the Eyes. Bone Marrow is occasionally used in TCM as a Yin and Essence tonic.
-most effective physiologic cholagogue; biliousness; biliary insufficiency -stimulates hemopoiesis
-cholecystitis, cholelithiasis -anemia, malnutrition, leukemia
-catarrhal Jaundice -tuberculosis, Bright’s disease
-eliminates intestinal putrefaction and breaks down intestinal mucus -splenomegaly and chronic Malaria
-mucous colitis, enteritis -Marrow was traditionally used externally to soften hardness and Tumors. (Galen)
-stimulates bowels; constipation DOSE: 5–10 grains of dried extract
-useful for Tuberculosis, toxic neurasthenia, migraine with Liver insufficiency. Placenta
CAUTION: not in obstructive Jaundice Placenta preferable from sheep, also cows;
COMBINATIONS: often used with Liver or Pancreas Human placenta is still used in TCM, and was formerly occasionally used in the Western Tradition. It is viewed as a potent Blood, Qi, Yin, Yang and Essence tonic, useful for marked debility.
DOSE: 2–5 grains dried; 5–15 grains inspissated; often used in enteric coated pills. -useful Postpartum tonic
Blood (Hemoglobin) -promotes milk
Red blood cells of cattle or other domestic animals. -prevents atrophy of the uterus
Several different Blood extracts were prepared including Serum and Anti-thyroid serum. COMBINATIONS: with Total Pituitary
Dried Blood, especially of a Goat, was used in the Western Tradition for Stones. Other Blood was used against Poison in various systems. The Chinese regularly coagulate Blood and cook it.
-all forms of anemia including chlorosis; anemia after severe blood loss.
-malnutrition
-hypothyroidism (especially in children)
-syphilitic and cancerous cachexia
NOTE: this is effectively an iron supplement, but is far better absorbed than regular iron preparations.
DOSE: 3–5 grains
COMBINATIONS: Often with Thyroid, especially in anemia with signs of hypothyroidism; with Spleen extract and/or Bone marrow to increase Blood.

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Sample Organotherapy Combinations:

Development Stimulant for Children Paralysis agitans (Parkinsonism)
  Pituitary (anterior)   Parathyroid
  Thymus gland   Testes
  Thyroid gland   Bile Salts
Galactogogue Functional Hypertension
  Placenta   Pancreas
  Mammary gland   Thyroid
  Pituitary (total) Senility, Asthenia and Prostate Disease
Functional Ovarian disorders   Testes
  Ovary   Thyroid
  Thyroid Asthenia, Neurasthenia, General Debility
  Pituitary (total)   Thyroid
Increasing Cellular Nutrition   Pituitary
  Liver   Testes
  Spleen   Adrenal
  Bile salts
  Adrenal

Suggested Organotherapy with Traditional Medicine
Blood Deficiency: Liver extract, Spleen extract with Si Wu Tang
Impotence: Testes extract with Liu Wei Di Huang Wan, Shen Qi Wan or Diasatyrion (Electuary of Orchis)
General Debility in Men: Testes extract with Si Jun Zi Tang or You Gui Wan
General Debility in Women: Ovary extract with Si Wu Tang or Xiao Yao San
Adrenal Weakness: Adrenal gland extract with Shen Qi Wan
Neurasthenia or Melancholy: Brain extract, Adrenal extract with Xiao Yao San or Leatificans
Prostate disease: Testes extract, Thyroid extract, Zhi Bai Di Huang Wan
Essence Tonic: Placenta extract, Bone Marrow extract with You Gui Wan or Zuo Gui Wan
Immune Deficiency: Thymus extract with Si Jun Zi Tang or Bu Zhong Yi Qi Tang
Severe Digestive Debility: Stomach extract or Chicken Gizzard Skin with Xiang Sha Liu Jun Zi Tang or Diacinnamonum


See also
Introduction to the Use of Animal Medicines
Animal Materia Medica
Animal Organs and By-products


Sample Adverts for Glandular Extracts
(Sourced from medical literature, circa 1910–20)

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