Scutellaria baicalensis, Huang Qin 黄芩
Huang Qin (TCM)
Scutellaria baicalensis
Curtis’s Botanical Magazine, 1849
Scutellaria baicalensis
(Photo: National Institute of Ecology, Korea)
Botanical name:
Scutellaria baicalensis
Parts used:
Root
Temperature & Taste:
Cold, dry. Bitter
Classification:
Uses:
1. Clears Heat and Damp:
-Diarrhea, Dysentery
-Fever, stifling sensation in Chest, Thirst
-Painful or Dribbling Urine
-Auxiliary for Jaundice
2. Clears Heat, Resists Toxin:
-Fever, Irritability, Thirst
-acute Cough with yellow sputum
-Heat-types Sores, Infections and Swellings
-important herb for acute bacterial infections
3. Clears Liver Heat:
-Headache, Red Eyes and Face, Restlessness, Anger, Bitter taste in the mouth
-Hypertension associated with Liver heat
4. Clears Heat, Stops Bleeding:
-Heat-type Blood in the Urine or Stool, Coughing or Vomiting Blood
5. Clears Heat, Calms the Fetus:
-Restless Fetus (excess movement or kicking)
Main Combinations:
Fever, Acute Disease:
1. Acute Fever with Heat and Toxin, Scutellaria Huang Qin with … available in PRO version
2. High Fever, Irritability, or Acute Swollen Sore Throat, Boils, Abscesses … available in PRO version
3. Fever and irritability; damp heat diarrhea, Jaundice; red and swollen eyes; carbuncle … available in PRO version
4. Alternating Fever and Chills, Scutellaria Huang Qin with … available in PRO version
5. Malarial disorders, … available in PRO version
6. Lesser Yang disorders with Chills and Fever, fullness in the chest and hyponchondria; and acute Phlegm-Heat disorders, Scutellaria Huang Qin with … available in PRO version
7. Shao Yang disease, Scutellaria Huang Qin with … available in PRO version
Heat and Toxin:
8. Acute Heat diseases affecting the Head, Scutellaria Huang Qin with … available in PRO version
9. Childhood convulsions from Heart Fire, Scutellaria Huang Qin with … available in PRO version
10. Broad-spectrum antibacterial for Heat and Toxin, Scutellaria Huang Qin, … available in PRO version
11. Dysentery with Blood, Scutellaria Huang Qin with, … available in PRO version
12. Herpes or Viral Hepatitis, … available in PRO version
13. Fever, swelling and pain in the Head, Mouth or Throat, … available in PRO version
14. Carbuncles and Internal or External Abscesses:
i. Scutellaria Huang Qin with … available in PRO version
ii Scutellaria Huang Qin with, with … available in PRO version
15. Eczema, Scutellaria Huang Qin with … available in PRO version
Cough, Bronchitis:
16. Heat-type Cough:
i. acute Cough with yellow Sputum or Hot and dry Lungs, Scutellaria Huang Qin with … available in PRO version
ii. acute Heat-type Cough, Scutellaria Huang Qin with … available in PRO version
iii. Heat-type Cough, Scutellaria Huang Qin with … available in PRO version
iv. Phlegm-heat Cough, Scutellaria Huang Qin, … available in PRO version
iv. Chronic Bronchitis, Scutellaria Huang Qin with … available in PRO version
17. Lung Heat Cough, Scutellaria Huang Qin … available in PRO version
Liver Heat, Jaundice:
18. Liver Heat:
i. Scutellaria Huang Qin with … available in PRO version
ii. Scutellaria Huang Qin with … available in PRO version
iii. Scutellaria Huang Qin with … available in PRO version
19. Liver heat Headache, Red Eyes, Irritability:
i. Scutellaria Huang Qin with … available in PRO version
ii. Liver Wind-Heat with Dizziness, Scutellaria Huang Qin with … available in PRO version
20. Sore, Red Eyes from Liver heat or Wind-Heat:
i. Wind-Heat, Scutellaria Huang Qin with … available in PRO version
ii. Liver heat, Scutellaria Huang Qin with … available in PRO version
21. Damp-Heat Jaundice
i. Scutellaria Huang Qin with … available in PRO version
ii. Damp-Heat Jaundice with Fever, Scutellaria Huang Qin with … available in PRO version
Heat-type Bleeding:
22. Bleeding from Heat:
i. from Heat and Yin deficiency, Scutellaria Huang Qin with … available in PRO version
ii. Vomiting of Blood, Scutellaria Huang Qin with … available in PRO version
iii. Blood in the Stool from Heat, Scutellaria Huang Qin with … available in PRO version
iv. Diarrhea and Dysentery with Blood, Scutellaria Huang Qin with … available in PRO version
v. Vomiting of Blood from Heat, Scutellaria Huang Qin with … available in PRO version
Other:
23. Heat and Damp affecting the Stomach, Scutellaria Huang Qin with … available in PRO version
24. Restless Fetus, Scutellaria Huang Qin with … available in PRO version
Major Formulas:
Xiao Chai Hu Tang
Da Chai Hu Tang
Huang Lian Jie Du Tang
Niu Huang Jie Du Pian
Dang Gui Liu Huang Tang
Long Dan Xie Gan Tang
Fang Feng Tong Sheng San
Tian Ma Gou Teng Yin
Da Huang Zhe Chong Wan
Cautions:
1. Not used in Cold and Weakness of the Digestive system.
Main Preparations used:
GENERAL / REVIEW
–Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology.
–A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis
–Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review
–Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots
–Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods
–Traditional uses, ten-years research progress on phytochemistry and pharmacology, and clinical studies of the genus Scutellaria
COMBINATIONS
–Pharmaceutical Advantages of GenoTX-407, A Combination of Extracts from Scutellaria baicalensis Root and Magnolia officinalis Bark
–The Combination of Scutellaria baicalensis Georgi and Sophora japonica L. ameliorate Renal Function by Regulating Gut Microbiota in Spontaneously Hypertensive Rats
–Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model
–Herbal Combination of Phyllostachys pubescens and Scutellaria baicalensis Inhibits Adipogenesis and Promotes Browning via AMPK Activation in 3T3-L1 Adipocytes
–Whether Co-Administration of Garlic has Negative Influence on Scutellaria Baicalensis Georgi in Treating Models Rats with Pelvic Inflammation?
–Analgesic Effects of a Standardized Biofavonoid Composition from Scutellaria baicalensis and Acacia catechu
–A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee
–Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu
–The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota
–Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach
–The Medicinal Plant Pair Bupleurum chinense–Scutellaria baicalensis – Metabolomics and Metallomics Analysis in a Model for Alcoholic Liver Injury
ANTI-INFLAMMATORY
–Comparison of Anti-Inflammatory and Anti-Nociceptive Activities of Curcuma Wenyujin Y.H. Chen et C. Ling and Scutellaria Baicalensis Georgi
–Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF- κB and MAPK in RAW 264.7 Cells
ANTI-ALLERGY
–Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release
ANTI-VIRAL
–Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice
–Extract of Scutellaria baicalensis inhibits dengue virus replication
–Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses
–Antiviral Properties of Baicalin: a Concise Review
COVID
–Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review
–Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro
–The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
ANTI-FUNGAL
–Antifungal activity and mechanism of action of Ou-gon (Scutellaria root extract) components against pathogenic fungi
EFFECT ON COPD FROM SMOKING
–Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model
ALCOHOLIC LIVER INJURY
–The Medicinal Plant Pair Bupleurum chinense–Scutellaria baicalensis – Metabolomics and Metallomics Analysis in a Model for Alcoholic Liver Injury
PULMONARY FIBROSIS
–Baicalin alleviates bleomycin-induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway
–A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis
CARDIOVASCULAR EFFECT
–Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review
CARDIOPROTECTIVE
–Baicalein Protects Against Doxorubicin-Induced Cardiotoxicity by Attenuation of Mitochondrial Oxidant Injury and JNK Activation
IMMUNE EFFECT
–Investigation of the immune effects of Scutellaria baicalensis on blood leukocytes and selected organs of the chicken’s lymphatic system
HEPATOPROTECTIVE
–Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
NEPHROPROTECTIVE
–Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response
NEUROPROTECTIVE
–Characterizing the Neuroprotective Effects of S/B Remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) in Spinal Cord Injury
–Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice
–Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review
–Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation
–Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis
COGNITION IMPROVER
–Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts from Scutellaria baicalensis and Acacia catechu
–Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review
PARKINSON’S DISEASE
–Baicalin Represses C/EBPβ via Its Antioxidative Effect in Parkinson’s Disease
ANTI-DEPRESSANT
–Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea
ANTI-HYPERTHYROID
–Therapeutic Effect of Scutellaria baicalensis on L-Thyroxine-Induced Hyperthyroidism Rats
ANTI-DIARRHEA
–Anti-diarrheal effect of Scutellaria baicalensis is associated with suppression of smooth muscle in the rat colon
COLITIS / ULCERATIVE COLITIS / INFLAMMATORY BOWEL DISEASE
–Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model
–Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach
–The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat
–Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine
–Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis
–Baicalin down regulates the expression of TLR4 and NFkB-p65 in colon tissue in mice with colitis induced by dextran sulfate sodium
ANTI-OBESITY
–Antiobesity Effects of the Combined Plant Extracts Varying the Combination Ratio of Phyllostachys pubescens Leaf Extract and Scutellaria baicalensis Root Extract
MIGRAINE
–The Effectiveness of Scutellaria baicalensis on Migraine: Implications from Clinical Use and Experimental Proof
PRURITIS
–Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice
OSTEOARTHRITIS
–A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee
CANCER
–The Extraction, Anticancer Effect, Bioavailability, and Nanotechnology of Baicalin
–Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors
BRAIN
–Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells
BREAST
–Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells
COLORECTAL
–Baicalin, the major component of traditional Chinese medicine Scutellaria baicalensis induces colon cancer cell apoptosis through inhibition of oncomiRNAs
–Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway
–Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence
–Inhibition of Autophagy Amplifies Baicalein-Induced Apoptosis in Human Colorectal Cancer
HEMATOLOGICAL CANCER
–Exploring Therapeutic Potentials of Baicalin and Its Aglycone Baicalein for Hematological Malignancies
LEUKEMIA
–Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells
LIVER
–Baicalin induces apoptosis in hepatic cancer cells in vitro and suppresses tumor growth in vivo
LUNG
–The Root Extract of Scutellaria baicalensis Induces Apoptosis in EGFR TKI-Resistant Human Lung Cancer Cells by Inactivation of STAT3
–Scutellaria baicalensis and Their Natural Flavone Compounds as Potential Medicinal Drugs for the Treatment of Nicotine-Induced Non-Small-Cell Lung Cancer and Asthma
ORAL
–The potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on human oral squamous cell carcinoma cells
–Exploring the Mechanism of Scutellaria baicalensis Georgi Efficacy against Oral Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking Analysis
OVARIAN
–Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell
–Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
PANCREATIC
–BAICALEIN, A COMPONENT OF SCUTELLARIA BAICALENSIS, INDUCES APOPTOSIS BY MCL-1 DOWN-REGULATION IN HUMAN PANCREATIC CANCER CELLS
–Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways
MELANOMA
–Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
SYNERGY WITH CHEMOTHERAPY
–Baicalin Enhances Chemosensitivity to Doxorubicin in Breast Cancer Cells via Upregulation of Oxidative Stress-Mediated Mitochondria-Dependent Apoptosis
–Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell
–Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
